Ethylorthoformate → 4-pentyl-1,4-dihydro-9H-[1,2,4]triazolo[1,5-a]purin-9-one
反应方程式
[NH2:1][N:2]1[C:10](=[O:11])[C:9]2[NH:8][CH:7]=[N:6][C:5]=2[N:4]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:3]1=[NH:17].[CH:18]([O-])([O-])OCC>>[CH2:12]([N:4]1[C:5]2[N:6]=[CH:7][NH:8][C:9]=2[C:10](=[O:11])[N:2]2[N:1]=[CH:18][N:17]=[C:3]12)[CH2:13][CH2:14][CH2:15][CH3:16]参与物
3
反应条件
- 温度
- 100 °C
实验过程
The mixture of 1-amino-2-imino-3-pentyl-1,2,3,7-tetrahydro-6H-purin-6-one (0.10 g, 0.4 mmol) and ethyl orthoformate (5 mL, 30 mmol) was stirred at 100° C. for 6 hours. The reaction mixture was concentrated and purified by preparative LCMS to yield the desired product (20 mg, 20%). LCMS calculated for C11H15N6O (M+H): 247.1. Found: 247.1.
后处理
- concentrationThe reaction mixture was concentrated
- custompurified by preparative LCMS
来源与证据
- ORD记录
- ord-3356b5a6e724474cae98ee8f940e459f
- 来源数据集
- uspto-grants-2014_04
- 专利号
- US08703783B2
反应笔记
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