4-氟联苯 → 4'-Fluorobiphenyl sulfonic acid

HRID 2425129笔记

反应方程式

HRID 2425129 反应方程式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参与物

4

反应物 2

HCID 94614-氟联苯HCID 24638氯磺酸

产物 1

HCID 181795134'-Fluorobiphenyl sulfonic acid

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

4′-Fluorobiphenyl (5 g) was dissolved in chloroform (100 mL) at room temperature. Chlorosulfonic acid (5 g) was added dropwise and stirring was continued for a further 4 hours, after which the solvent was allowed to slowly evaporate until precipitation was seen. The mixture was left to recrystallised overnight and the solid was collected by filtration. Further crops of crystals were collected from the filtrate.

后处理

  1. customto slowly evaporate until precipitation
  2. waitThe mixture was left
  3. customto recrystallised overnight
  4. filtrationthe solid was collected by filtration
  5. customFurther crops of crystals were collected from the filtrate

来源与证据

ORD记录
ord-cac7a01dc1c048cab8ea26a96b5eb42f
来源数据集
uspto-grants-2011_06
专利号
US07964643B2

反应笔记

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