反应方程式
NCc1ccccc1.O=C1NCCc2cc(Br)ccc21>CC(=O)O.CC(=O)O.C[O-].Cc1ccccc1.[Na+].[Pd].c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1>O=C1NCCc2cc(NCc3ccccc3)ccc21参与物
7
反应条件
- 温度
- 110 °C
实验过程
In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.
来源与证据
- ORD记录
- ord-08bf18171af14ad9bb3d94faf7cd7b73
- 来源数据集
- 750 AstraZeneca ELN dataset
- 原始链接
- 查看来源
关联笔记
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