对羟基苯甲酸 → Benzoic acid, 4-((1-oxodecyl)oxy)-

HRID 247784

反应方程式

HRID 247784 反应方程式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:18](Cl)(=[O:28])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].Cl>ClCCl.CN(C1C=CC=CN=1)C>[C:18]([O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)(=[O:28])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

参与物

7

反应物 4

HCID 135对羟基苯甲酸HCID 313海萝胶HCID 8471三乙胺HCID 66982癸酰氯

产物 1

HCID 3608562Benzoic acid, 4-((1-oxodecyl)oxy)-收率 78.7%

试剂、催化剂与溶剂 2

HCID 218852-二甲氨基吡啶催化剂HCID 6344二氯甲烷溶剂

实验过程

To a solution of p-hydroxybenzoic acid (3 g) and triethylamine (2.4 g) in dichloromethane (30 ml) were added decanoyl chloride (4.3 g) and dimethylaminopyridine (0.2 g). The mixture was stirred at room temperature for about 20 hours. After dilute aqueous hydrochloric acid solution was added to the mixture, an organic layer was separated by a funnel. After the solution was distilled to remove the solvent, the residue was washed with n-hexane and dried to obtain the titled compound (about 5 g).

后处理

  1. customan organic layer was separated by a funnel
  2. distillationAfter the solution was distilled
  3. customto remove the solvent
  4. washthe residue was washed with n-hexane
  5. customdried

来源与证据

ORD记录
ord-d0f29f1ace974ea1bd0bc63aa6f31766
来源数据集
uspto-grants-1993_05
专利号
US05207947

关联笔记

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