碳酸钾 → [2-Chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)phenyl] 2,2,2-trifluoroethyl sulfide

HRID 25282

反应方程式

HRID 25282 反应方程式
[S:1]([C:19]1C=C(C2N(C(F)(F)F)N=NC=2)C(F)=CC=1Cl)[C:2]1[CH:7]=[C:6]([C:8]2[N:9]([C:13]([F:16])([F:15])[F:14])[N:10]=[N:11][CH:12]=2)[C:5]([F:17])=[CH:4][C:3]=1[Cl:18].C(S([O-])=O)O.[Na+].C(=O)([O-])[O-].[K+].[K+].[F:48][C:49]([F:53])([F:52])CI>>[F:48][C:49]([F:53])([F:52])[CH2:19][S:1][C:2]1[CH:7]=[C:6]([C:8]2[N:9]([C:13]([F:15])([F:16])[F:14])[N:10]=[N:11][CH:12]=2)[C:5]([F:17])=[CH:4][C:3]=1[Cl:18]

参与物

5

反应物 4

HCID 11430碳酸钾HCID 677092-碘-1,1,1-三氟乙烷HCID 221709141,1'-Thiodi-[2-chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)benzene]HCID 23689980次硫酸氢钠甲醛

产物 1

HCID 86587601[2-Chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)phenyl] 2,2,2-trifluoroethyl sulfide收率 96.6%

实验过程

1.8 g (3.0 mmol) of 1,1′-thiodi-[2-chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)benzene], 2.0 g (13.0 mmol) of Rongalite, 2.0 g (14.5 mmol) of potassium carbonate and 3.2 g (17.6 mmol) of 2,2,2-trifluoroethyl iodide were reacted in the same way as in Example 2 (3) and afforded 1.1 g of [2-chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)phenyl] 2,2,2-trifluoroethyl sulfide (yield 47.8%) as white crystals (m.p. 56-58° C.).

来源与证据

ORD记录
ord-8be04ddb476d488398190c4032a8b95d
来源数据集
uspto-grants-2005_02
专利号
US06858639B2

关联笔记

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