二苄胺 → N,N-二苄基甲酰胺

HRID 26585

反应方程式

HRID 26585 反应方程式
[CH2:1]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:18]

参与物

4

反应物 2

HCID 7656二苄胺HCID 7918乙酐

产物 1

HCID 221415N,N-二苄基甲酰胺

试剂、催化剂与溶剂 1

HCID 284甲酸溶剂

实验过程

To an ice-cold and vigorously stirred solution of dibenzylamine (918 g.) in 98% formic acid (105 ml.) is added dropwise, over 45 minutes, acetic anhydride (35 ml.). The resulting mixture is stirred for one hour at room temperature, then diluted with ice water (40 ml.) and kept overnight at 15° C. The solution is evaporated in vacuo to dryness and the residue extracted with ether. The ethereal solution is washed with water, dried over magnesium sulfate, filtered, and evaporated in vacuo to yield N-formyl-dibenzylamine (9.9 g.) as a white solid, m.p. 53°-54.5° C.

后处理

  1. waitkept overnight at 15° C
  2. customThe solution is evaporated in vacuo to dryness
  3. extractionthe residue extracted with ether
  4. washThe ethereal solution is washed with water
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated in vacuo

来源与证据

ORD记录
ord-03a6fa7a7c6147029957a8734a984a23
来源数据集
uspto-grants-1979_04
专利号
US04150223

关联笔记

加载中…