丙酸 → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone

HRID 2796

反应方程式

HRID 2796 反应方程式
Cl[CH:2]([C:6](=[O:8])[CH3:7])[C:3](=O)[CH3:4].[C:9]([NH2:13])(=[O:12])[CH2:10][CH3:11].C(O)(=O)CC.[OH-].[Na+]>>[C:6]([C:2]1[O:12][C:9]([CH2:10][CH3:11])=[N:13][C:3]=1[CH3:4])(=[O:8])[CH3:7]

参与物

5

反应物 4

HCID 1032丙酸HCID 6578丙酰胺HCID 14798二甲基对苯二胺二盐酸HCID 743283-氯-2，4-戊二酮

产物 1

HCID 189363281-(2-Ethyl-4-methyloxazol-5-yl)ethanone

实验过程

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

后处理

  1. extractionextracted with dichloromethane
  2. washThe combined extracts were washed with brine
  3. customdried
  4. customthe solvent removed
  5. customto leave a brown oil which
  6. distillationwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

来源与证据

ORD记录
ord-eb5bfefcbfd94ea0be77c604cb53b9bd
来源数据集
uspto-grants-1998_03
专利号
US05731335

关联笔记

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