氢氧化钾 → N-(哌啶-4-基)吡啶-2-胺

HRID 28131笔记

反应方程式

HRID 28131 反应方程式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][CH:8]1[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]1.[OH-].[K+]>CC(O)C>[NH:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:9][CH2:10]1

参与物

4

反应物 2

HCID 14797氢氧化钾HCID 11357119Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate

产物 1

HCID 21912674N-(哌啶-4-基)吡啶-2-胺

试剂、催化剂与溶剂 1

HCID 3776异丙醇溶剂

实验过程

A mixture of 90 parts of ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate, 90 parts of potassium hydroxide and 720 parts of 2-propanol is stirred and refluxed for 2 days. The reaction mixture is evaporated. 1000 Parts of water are added to the residue and the product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 13 parts of N-(4-piperidinyl)-2-pyridinamine.

后处理

  1. temperaturerefluxed for 2 days
  2. customThe reaction mixture is evaporated
  3. addition1000 Parts of water are added to the residue
  4. extractionthe product is extracted with dichloromethane
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue is crystallized from 2,2'-oxybispropane

来源与证据

ORD记录
ord-5de2252d3ef44a7e9f19d928761cf090
来源数据集
uspto-grants-1980_09
专利号
US04225606

反应笔记

加载中…