2-乙酰基噻吩 → 1-(4,5-Dimethyl-2-thiazolyl)-1-(2-thienyl)ethanol

HRID 2826

反应方程式

HRID 2826 反应方程式
C([Li])CCC.[CH3:6][C:7]1[N:8]=[CH:9][S:10][C:11]=1[CH3:12].[C:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:15])[CH3:14]>C(OCC)C>[CH3:6][C:7]1[N:8]=[C:9]([C:13]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)([OH:15])[CH3:14])[S:10][C:11]=1[CH3:12]

参与物

5

反应物 3

HCID 69202-乙酰基噻吩HCID 625104,5-二甲基噻唑HCID 178418339正丁基锂

产物 1

HCID 189363451-(4,5-Dimethyl-2-thiazolyl)-1-(2-thienyl)ethanol

试剂、催化剂与溶剂 1

HCID 3283乙醚溶剂2 次

实验过程

n-Butyllithium (2.5M solution in hexanes, 9.7 ml) was added dropwise to a stirred solution of 4,5-dimethylthiazole (2.5 g) in dry diethyl ether (30 ml) at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, 2-acetylthiophene (3.1 g) in diethyl ether (20 ml) was added dropwise. After a further 1 hour the mixture was allowed to warm to room temperature and was then worked up in the normal fashion to yield the title compound.

后处理

  1. waitAfter a further 1 hour the mixture was allowed

来源与证据

ORD记录
ord-b8d6ab59a04244b59a32293274773631
来源数据集
uspto-grants-1998_03
专利号
US05731335

关联笔记

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