邻氯苯胺 → 6-(5-Chloro-2-ethoxy-phenyl)-N4-(2-chloro-phenyl)-pyrimidine-2,4-diamine

HRID 28622

反应方程式

Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:16][CH3:17])[N:5]=[C:4]([NH2:18])[N:3]=1.[Cl:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH2:22]>>[Cl:14][C:12]1[CH:11]=[CH:10][C:9]([O:15][CH2:16][CH3:17])=[C:8]([C:6]2[N:5]=[C:4]([NH2:18])[N:3]=[C:2]([NH:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[Cl:19])[CH:7]=2)[CH:13]=1

参与物

反应物 2

HCID 7240邻氯苯胺

HCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

产物 1

HCID 443141316-(5-Chloro-2-ethoxy-phenyl)-N*4*-(2-chloro-phenyl)-pyrimidine-2,4-diamine收率 31%

实验过程

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 2-chloroaniline provided the title compound (31% yield). 1H NMR (DMSO-d6) δ 1.19-1.22 (t, 3H, CH3), 4.0-4.1 (q, 2H, CH2), 6.0-6.30 (s, 2H, NH2), 6.65 (s, 1H, Ar), 7.05-7.29 (m, 4H, Ar), 7.316 (d, 1H, Ar) 7.354 (d, 1H, Ar) 7.90 (d, 1H, Ar) 8.8 (br s, 1H, NH).

来源与证据

ORD记录: ord-473731f08edb4fc6bd00d07111c1c57f
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07419984B2

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