4-氯苯甲酰肼 → HCID 178465662，化合物

HRID 29807

反应方程式

HRID 29807 反应方程式
C[O-].[Na+].Cl.[C:5]([NH2:8])(=[NH:7])[CH3:6].[Cl:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([NH:16]N)=[O:15])=[CH:12][CH:11]=1>C(O)C>[NH:7]=[C:5]([NH:8][NH:16][C:14](=[O:15])[C:13]1[CH:18]=[CH:19][C:10]([Cl:9])=[CH:11][CH:12]=1)[CH3:6]

参与物

5

反应物 3

HCID 108164-氯苯甲酰肼HCID 67170盐酸乙脒HCID 10942334甲醇钠

产物 1

HCID 178465662HCID 178465662，化合物

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂2 次

实验过程

1.09 g (20 mmol) sodium methoxide in 20 mL ethanol are added to a solution of 1.91 g (20 mmol) acetamidine hydrochloride in 30 mL ethanol. The mixture is stirred for 30 minutes at ambient temperature and then filtered. The filtrate is combined with 2.3 g (13.5 mmol) 4-chlorobenzoic acid hydrazide, stirred overnight at ambient temperature, cooled with an ice bath and then filtered. The precipitate is washed with cold ethanol and dried. Yellow solid. Yield: 1.45 g (51%); mass spectroscopy [M+H]+=212/214.

后处理

  1. filtrationfiltered
  2. stirringstirred overnight at ambient temperature
  3. temperaturecooled with an ice bath
  4. filtrationfiltered
  5. washThe precipitate is washed with cold ethanol
  6. customdried

来源与证据

ORD记录
ord-496ee62380ad4f8f9002a4d76b272e6b
来源数据集
uspto-grants-2008_09
专利号
US07423036B2

关联笔记

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