四氢呋喃 → 3-甲氧基-4-氯苯胺

HRID 31356

反应方程式

HRID 31356 反应方程式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12].C1COCC1>[Ni].CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[O:11][CH3:12]

参与物

5

反应物 2

HCID 8028四氢呋喃HCID 705192-氯-5-硝基茴香醚

产物 1

HCID 131036923-甲氧基-4-氯苯胺收率 92.6%

试剂、催化剂与溶剂 2

HCID 935Nickel催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

A mixture of 36 g of 2-chloro-5-nitroanisole and Raney nickel® in 150 ml of MeOH and 200 ml of THF is hydrogenated in Parr apparatus for 4 hours, at 35° C. and under a pressure of 1.3 bar. The catalyst is filtered off over Celite® and the filtrate is concentrated under vacuum. 28 g of the expected product are obtained and are used without further purification.

后处理

  1. filtrationThe catalyst is filtered off over Celite®
  2. concentrationthe filtrate is concentrated under vacuum

来源与证据

ORD记录
ord-a77733feb375483f93c36535d0ed4529
来源数据集
uspto-grants-2008_09
专利号
US07425566B2

关联笔记

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