乙醚 → (1-(3-carboethoxypropyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid salt

反应方程式

[C:1]([CH2:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]=[C:10]1[NH:18][CH:19]1[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]1)([O:3][CH2:4][CH3:5])=[O:2].[IH:32].C(OCC)C>C(O)C>[IH:32].[C:1]([CH2:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]=[C:10]1[NH:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)([O:3][CH2:4][CH3:5])=[O:2]

参与物

实验过程

Combine (1-(3-carboethoxypropyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine (0.59 g, 1.37 mmol) and aqueous hydriodic acid (2 mL, 57%) in ethanol (25 mL). Heat to reflux. After 2 hours, cool to ambient temperature, pour the reaction mixture into diethyl ether (450 mL), and cool to about −30° C. to give a solid. Collect the solid by filtration and dry to give the title compound.