化工社化工社化学信息打印报告 · 仅供科研参考
六氢吡啶 → 1-(2-Methyl-6-nitrophenyl)piperidine
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 六氢吡啶 | HCID 8082 | — |
| 反应物 | 2-氯-3-硝基甲苯 | HCID 77591 | — |
| 产物 | 1-(2-Methyl-6-nitrophenyl)piperidine | HCID 12798213 | 35% |
反应步骤
Using a procedure similar to Example 8, step (a), 2-chloro-3-methylnitrobenzene (264 mg, 1.53 mmol) was heated to 110° C. overnight in 3 mL of piperidine to afford 128 mg (35%) of the title compound and an undetermined amount of starting material. 1H-NMR (CDCl3; 400 MHz): δ 7.41-7.34 (m, 2H), 7.02 (t, 1H, J=7.7 Hz), 2.96-2.93 (m, 4H), 2.36 (s, 3H), 1.65 (br s, 6H).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07427683B2 |
| 来源数据集 | uspto-grants-2008_09 |
| ORD ID | ord-be105cc7411f4b82a395347f5ce226f9 |
| 来源说明 | uspto-grants-2008_09 |