乙醇 → 1 - (2-甲氧基苯基)-1H -吡唑

HRID 337331笔记

反应方程式

HRID 337331 反应方程式
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][NH2:11].O.[C:13](=O)([O-])[O-].[Na+].[Na+].[CH2:19](O)[CH3:20]>>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH:20]=[CH:19][CH:13]=[N:11]1

参与物

5

反应物 4

HCID 702乙醇HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 10340Carbonic acid sodium salt (1:2)HCID 28494452-甲氧基苯肼盐酸盐

产物 1

HCID 112867471 - (2-甲氧基苯基)-1H -吡唑

实验过程

200 mg of 2-methoxyphenyl hydrazine hydrochloride was dissolved in 5 ml of ethanol, and 189 μl of malonaldehyde bisdimethylacetal was added and heated at reflux for 2 hours. To the reaction mixture was added 50 ml of water, neutralized with a saturated aqueous solution of sodium carbonate, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 179.4 mg of the title compound.

后处理

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. extractionextracted with 60 ml of ethyl acetate
  4. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

来源与证据

ORD记录
ord-f40f54081c424eedbe16a9367a5ae4ae
来源数据集
uspto-grants-2014_11
专利号
US08889727B2

反应笔记

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