2-Hydrazinyl-4-(2-methoxyethoxy)pyridine → N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-(2-methoxyethoxy)pyridin-2-amine

HRID 339663笔记

反应方程式

HRID 339663 反应方程式
[NH:1]([C:3]1[CH:8]=[C:7]([O:9][CH2:10][CH2:11][O:12][CH3:13])[CH:6]=[CH:5][N:4]=1)[NH2:2].[Si:14]([O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:31]=1[N:30]=[C:29]([CH:32]=O)[CH:28]=[CH:27]2)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]>CCO>[Si:14]([O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:31]=1[N:30]=[C:29](/[CH:32]=[N:2]/[NH:1][C:3]1[CH:8]=[C:7]([O:9][CH2:10][CH2:11][O:12][CH3:13])[CH:6]=[CH:5][N:4]=1)[CH:28]=[CH:27]2)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:15])[CH3:16]

参与物

4

反应物 2

HCID 552790432-Hydrazinyl-4-(2-methoxyethoxy)pyridineHCID 585670828-(Tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde

产物 1

HCID 173055441N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-(2-methoxyethoxy)pyridin-2-amine收率 56%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

2-Hydrazinyl-4-(2-methoxyethoxy)pyridine (0.076 g, 0.415 mmol) and 8-(tert-butyldimethylsilyloxy) quinoline-2-carbaldehyde (0.119 g, 0.415 mmol) were heated to reflux in EtOH (2 mL) for 16 hours. After cooling to ambient temperature the reaction mixture was filtered and washed with EtOH to provide 105 mg (56%) of desired product as an orange solid.

后处理

  1. filtrationwas filtered
  2. washwashed with EtOH

来源与证据

ORD记录
ord-54203cd3635c4e7f9b56a7890bb40afa
来源数据集
uspto-grants-2014_11
专利号
US08895550B2

反应笔记

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