乙酐 → HCID 10968127，化合物

HRID 341745

反应方程式

HRID 341745 反应方程式
[CH3:1][CH:2]([CH2:4][C@H:5]([NH2:17])[C:6]([NH:8][C@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:7])[CH3:3].C(=O)([O-])[O-].[K+].[K+].[C:24](OC(=O)C)(=[O:26])[CH3:25]>O.CCOCC>[NH:17]([C:24]([CH3:25])=[O:26])[C@H:5]([C:6]([NH:8][C@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:12])[CH3:13])=[O:7])[CH2:4][CH:2]([CH3:1])[CH3:3]

参与物

6

反应物 3

HCID 7918乙酐HCID 11430碳酸钾HCID 76807L-亮氨酸二肽

产物 1

HCID 10968127HCID 10968127，化合物收率 74%

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 3283乙醚溶剂

实验过程

Leu-Leu (1.0 g, 3.8 mmol) and potassium carbonate (7.0 g, 5 mmol) are dissolved in 100 ml of water. The solution is cooled with ice and 5.0 ml acetic anhydride in 50 ml of ether is added dropwise under vigorous stirring. Stirring is continued for one hour, then the ice-bath is removed and the stirring continued for further 2 hours. The water phase is separated, acidified with hydrochloric acid. The precipitate is stirred for one hour, filtered, washed with water and dried yielding 0.8 gram (74%) of Ac-Leu-Leu.

后处理

  1. additionis added dropwise under vigorous stirring
  2. customthe ice-bath is removed
  3. waitthe stirring continued for further 2 hours
  4. customThe water phase is separated
  5. stirringThe precipitate is stirred for one hour
  6. filtrationfiltered
  7. washwashed with water
  8. customdried

来源与证据

ORD记录
ord-40ae03f1a2324e9483dcb5b228086a74
来源数据集
uspto-grants-1999_01
专利号
US05856306

关联笔记

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