参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 海萝胶 | HCID 313 | — |
| 反应物 | 6-Acetylamino-2-methyl-3-nitro-benzoic acid | HCID 15283171 | — |
| 溶剂 | 二甲基对苯二胺二盐酸 | HCID 14798 | — |
| 产物 | 6-氨基-2-甲基-3-硝基苯甲酸 | HCID 15283172 | — |
反应步骤
450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for one hour. After cooling to 10° C., it is acidified by addition of 425 ml of 2N HCl, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 50.7 g (0.258 mol)=82% of theory, m.p.: 183°-184° C.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 专利号 | US05863864 |
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| 来源数据集 | uspto-grants-1999_01 |
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| ORD ID | ord-e142719f3f5846c98226c035ba74df6b |
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| 来源说明 | uspto-grants-1999_01 |
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