海萝胶 → 6-氨基-2-甲基-3-硝基苯甲酸

HRID 343745

反应方程式

HRID 343745 反应方程式
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([NH:14]C(=O)C)[C:3]=1[C:4]([OH:6])=[O:5].Cl>[OH-].[Na+]>[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([NH2:14])[C:3]=1[C:4]([OH:6])=[O:5]

参与物

4

反应物 2

HCID 313海萝胶HCID 152831716-Acetylamino-2-methyl-3-nitro-benzoic acid

产物 1

HCID 152831726-氨基-2-甲基-3-硝基苯甲酸

试剂、催化剂与溶剂 1

HCID 14798二甲基对苯二胺二盐酸溶剂

反应条件

温度
95 °C

实验过程

450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for one hour. After cooling to 10° C., it is acidified by addition of 425 ml of 2N HCl, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 50.7 g (0.258 mol)=82% of theory, m.p.: 183°-184° C.

后处理

  1. temperatureAfter cooling to 10° C.
  2. filtrationthe precipitate which deposits is filtered off with suction
  3. washwashed with water
  4. customdried under reduced pressure at 50° C

来源与证据

ORD记录
ord-e142719f3f5846c98226c035ba74df6b
来源数据集
uspto-grants-1999_01
专利号
US05863864

关联笔记

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