碘甲烷 → 4-(3-Methoxyphenyl)morpholine

HRID 349695

反应方程式

HRID 349695 反应方程式
[N:1]1([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:14]([O-])([O-])=O.[K+].[K+].IC>CN(C=O)C.CCOCC>[CH3:14][O:13][C:9]1[CH:8]=[C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)[CH:12]=[CH:11][CH:10]=1

参与物

6

反应物 3

HCID 6328碘甲烷HCID 11430碳酸钾HCID 1413433-吗啉苯酚

产物 1

HCID 99643354-(3-Methoxyphenyl)morpholine

试剂、催化剂与溶剂 2

HCID 3283乙醚溶剂HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

To a stirred mixture of 3-morpholinyl-phenol (3.8 g; 21.2 mmol) and powdered K2CO3 (4.4 g; 31.8 mmol) in dry DMF (15 mL) was added iodomethane (1.45 mL; 23.3 mmol) via syringe at room temperature under nitrogen atmosphere. The resulting mixture was allowed to stir at room temperature for 22 hours. The reaction was diluted with ether (150 mL) and washed successively with water (2×40 mL) and brine (40 mL), then dried (MgSO4), filtered and concentrated in vacuo to provide the desired ether as a yellow oil (2.51 g; 61%).

后处理

  1. washwashed successively with water (2×40 mL) and brine (40 mL)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customto provide the desired ether as a yellow oil (2.51 g; 61%)

来源与证据

ORD记录
ord-5888eead817d4f8ab60508cb457f9058
来源数据集
uspto-grants-2007_02
专利号
US07179912B2

关联笔记

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