3-(3-吲哚基)-2-氧代丙酸 → N-cyclohexyl 3-indolepyruvamide

HRID 359727笔记

反应方程式

HRID 359727 反应方程式
C[N-]C.[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH2:13][C:14](=[O:18])[C:15]([OH:17])=O)=[CH:5]1.[CH:19]1[CH:20]=[CH:21][C:22]2N(O)N=[N:25][C:23]=2[CH:24]=1.C1(N)CCCCC1.CN1CCOCC1>CCN=C=NCCCN(C)C.Cl>[CH:23]1([NH:25][C:15](=[O:17])[C:14]([CH2:13][C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:4][CH:5]=2)=[O:18])[CH2:24][CH2:19][CH2:20][CH2:21][CH2:22]1

参与物

7

反应物 5

HCID 8033-(3-吲哚基)-2-氧代丙酸HCID 7965环己胺HCID 7972N-甲基吗啉HCID 757711-羟基苯并三唑(HOBT)HCID 182180Dimethylazanide

产物 1

HCID 54134943N-cyclohexyl 3-indolepyruvamide

试剂、催化剂与溶剂 1

HCID 27239391-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐溶剂

实验过程

The same method as described in Example 7 was followed for the preparation of N,N-dimethylamide. 500 mg 3-indolepyruvic acid were reacted with 400 ml HOBt and 570 ml EDC.HCl. 340 microliters of freshly distilled cyclohexylamine and 325 microliters NMM were added to the solution, which was reacted for 5 hours.

后处理

  1. customwas reacted for 5 hours

来源与证据

ORD记录
ord-ab4f0216453f46f89472cb195305881f
来源数据集
uspto-grants-1991_03
专利号
US05002963

反应笔记

加载中…