聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 5,8-Dihydro-2-methyl 1,4-naphthoquinone

HRID 36088

反应方程式

HRID 36088 反应方程式
[C:1]1([CH3:9])[C:2](=O)[C:3](=[O:7])[CH:4]=[CH:5][CH:6]=1.[CH2:10]=[CH:11][CH:12]=[CH2:13].[Cl-].[Li+].[OH2:16]>C1(C)C=CC=CC=1.C(O)(=O)C>[CH3:9][C:1]1[C:6](=[O:16])[C:5]2[CH2:10][CH:11]=[CH:12][CH2:13][C:4]=2[C:3](=[O:7])[CH:2]=1

参与物

7

反应物 4

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 78451,3-丁二烯HCID 433294氯化锂HCID 123257543-Methylcyclohexa-3,5-diene-1,2-dione

产物 1

HCID 190786525,8-Dihydro-2-methyl 1,4-naphthoquinone

试剂、催化剂与溶剂 2

HCID 176醋酸溶剂HCID 1140甲苯溶剂

实验过程

In toluene (30 ml) and acetic acid (5 ml), were dissolved 7.0 g (0,057 mol) of toluquinone, to which 7.6 g (0.14 mol) of 1,3-butadiene were added at -10° C. under stirring. Thereafter, the resultant mixture was gradually heated and stirred further for 3 hours at 40° C. The liquid reaction mixture was washed with water, and an organic layer was dried and concentrated under reduced pressure. Concentrated hydrochloric acid (1 ml) and ethanol (50 ml) were added to the residue, and the mixture was stirred for 1 hour at 40° C. After the liquid reaction mixture was concentrated under reduced pressure, the residue was dissolved in a liquid mixture of toluene (50 ml), n-propanol (25 ml) and water (25 ml). To the solution, were added 1.0 g (0.23 mol) of lithium chloride, 5.0 g (0.29 mol) of cupric chloride dihydrate to stir the resultant mixture for 1 hour at 40° C. The liquid reaction mixture was poured into water (100 ml) to make extraction with toluene (50 ml × 2). The resulting organic layer was washed with water, dried and concentrated under reduced pressure to obtain a crude product of the title compound. This crude product was recrystallized from methanol (20 ml) to obtain 9.14 g of the title compound as yellow crystals (yield: 92%).

后处理

  1. stirringstirred further for 3 hours at 40° C
  2. customThe liquid reaction mixture
  3. washwas washed with water
  4. customan organic layer was dried
  5. concentrationconcentrated under reduced pressure
  6. additionConcentrated hydrochloric acid (1 ml) and ethanol (50 ml) were added to the residue
  7. stirringthe mixture was stirred for 1 hour at 40° C
  8. customAfter the liquid reaction mixture
  9. concentrationwas concentrated under reduced pressure
  10. dissolutionthe residue was dissolved in a liquid mixture of toluene (50 ml), n-propanol (25 ml) and water (25 ml)
  11. customThe liquid reaction mixture
  12. extractionextraction with toluene (50 ml × 2)
  13. washThe resulting organic layer was washed with water
  14. customdried
  15. concentrationconcentrated under reduced pressure

来源与证据

ORD记录
ord-bd6a48f4d00c4bdb971168e509fefa7b
来源数据集
uspto-grants-1995_05
专利号
US05412124

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