苯乙酮 → 4'-甲氧基查耳酮

HRID 36738

反应方程式

HRID 36738 反应方程式
[OH-].[Na+].[CH:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1.[C:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=O)[CH3:14]>CCO.O>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3](=[O:12])[CH:14]=[CH:13][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:5][CH:6]=1

参与物

6

反应物 3

HCID 7410苯乙酮HCID 14798二甲基对苯二胺二盐酸HCID 31244大茴香醛

产物 1

HCID 928534'-甲氧基查耳酮收率 56%

试剂、催化剂与溶剂 2

HCID 702乙醇溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

Step A Add 10% aqueous NaOH (38 mL) to a solution of p-anisaldehyde (25 mL, 0.206 mol) and acetophenone (23.97 mL, 0.206 mol) in EtOH (500 mL). Stir the mixture at room temperature over night. Dilute the mixture with water and extract with ether. Combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to a solid. Recrystallize the solid from ether/hexanes to provide 27.51 g (56%) of 4'-methoxychalcone, mp 72°-74° C.

后处理

  1. extractionextract with ether
  2. washwash with water and brine
  3. dry with materialdry over Na2SO4
  4. concentrationconcentrate to a solid
  5. customRecrystallize the solid from ether/hexanes

来源与证据

ORD记录
ord-8a78853258fc48d2bcf415d810e7317d
来源数据集
uspto-grants-1995_05
专利号
US05416118

关联笔记

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