氢氧化钾 → Dimethyl (2-methoxy-phenylsulphanyl)malonate

HRID 37101笔记

反应方程式

HRID 37101 反应方程式
[OH-].[K+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[SH:11].Cl[CH:13]([C:18]([O:20][CH3:21])=[O:19])[C:14]([O:16][CH3:17])=[O:15]>C(O)C>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:13]([C:18]([O:20][CH3:21])=[O:19])[C:14]([O:16][CH3:17])=[O:15]

参与物

5

反应物 3

HCID 14797氢氧化钾HCID 236422-甲氧基苯硫酚HCID 120070氯代丙二酸二甲酯

产物 1

HCID 22362038Dimethyl (2-methoxy-phenylsulphanyl)malonate

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂2 次

实验过程

1 g of KOH was added to a solution of 2.2 ml of 2-methoxythiophenol in 30 ml of ethanol. The reaction mixture was treated at room temperature with a solution of dimethyl chloromalonate in 5 ml of ethanol, stirred for 1 hour and evaporated. The residue was partitioned between ether and water. The organic phase was dried, concentrated and the residue was purified over silica gel with methylene chloride. 3.6 g of dimethyl (2-methoxy-phenylsulphanyl)malonate, MS: M=270, were obtained.

后处理

  1. customevaporated
  2. customThe residue was partitioned between ether and water
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customthe residue was purified over silica gel with methylene chloride

来源与证据

ORD记录
ord-19e57d3a32fb454487ce6ca1e155c744
来源数据集
uspto-grants-1995_05
专利号
US05420129

反应笔记

加载中…