盐酸 → 6-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

HRID 371663笔记

反应方程式

HRID 371663 反应方程式
[N+:1]([C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:17])([F:16])[F:15])=[N:10][C:7]2=[N:8][CH:9]=1)([O-])=O.C(O)C.Cl.[H][H]>[Pd].O>[NH2:1][C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:15])([F:17])[F:16])=[N:10][C:7]2=[N:8][CH:9]=1

参与物

7

反应物 4

HCID 313盐酸HCID 702乙醇HCID 203554946-Nitro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-olHCID 178418361HCID 178418361，化合物

产物 1

HCID 203554676-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

试剂、催化剂与溶剂 2

HCID 23938钯碳催化剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

6-Nitro-1-hydroxy-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine (4.9 grams) was mixed with 100 milliliters of ethanol and 3 milliliters of concentrated hydrochloric acid, and 1 gram of 5 percent palladium on carbon was added to the mixture. The mixture was hydrogenated to a 3 mole-equivalent uptake of hydrogen. The reaction mixture was then filtered and evaporated, yielding a gummy solid residue which was taken up in 150 milliliters of water and used directly in the reaction reported in the following example.

后处理

  1. additionwas added to the mixture
  2. filtrationThe reaction mixture was then filtered
  3. customevaporated
  4. customyielding a gummy solid residue which

来源与证据

ORD记录
ord-9ee81935c37245bd9899f682e25f1938
来源数据集
uspto-grants-1978_05
专利号
US04087432

反应笔记

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