2-丁酮 → N-(2-butyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine

HRID 3759

反应方程式

HRID 3759 反应方程式
[NH2:1][C:2]([CH3:9])([CH3:8])[CH2:3][NH:4][CH2:5][CH2:6][NH2:7].[CH3:10][C:11](=O)[CH2:12][CH3:13].[H][H]>[Pt].CO>[CH3:10][CH:11]([NH:7][CH2:6][CH2:5][NH:4][CH2:3][C:2]([NH2:1])([CH3:9])[CH3:8])[CH2:12][CH3:13]

参与物

6

反应物 3

HCID 65692-丁酮HCID 10898752N,N'-(2-amino-2-methylpropyl)ethylenediamineHCID 178418361HCID 178418361，化合物

产物 1

HCID 11084593N-(2-butyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine收率 69.5%

试剂、催化剂与溶剂 2

HCID 23939铂催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

A mixture of 146 g (1.1 moles) of N-(2-amino-2-methylpropyl)-1,2-ethanediamine, 84.4 (1.17 moles) of 2-butanone, 300 ml methanol, and 3.0 g of 10% platinum on carbon were reacted in a 1 liter autoclave at 80° C. under 800 pounds per square inch (psi) hydrogen pressure. After two hours the reaction mixture was cooled, then filtered to remove the catalyst. The filtrate was stripped to give 205.3 g of water-white clear liquid which was fractionally distilled under reduced pressure. The desired product recovered was found to weigh 144.5 g (69.5% yield), and has a boiling point (b.p.) of 62°-64° C./0.15 mm Hg.

后处理

  1. temperatureAfter two hours the reaction mixture was cooled
  2. filtrationfiltered
  3. customto remove the catalyst
  4. customto give 205.3 g of water-white clear liquid which
  5. distillationwas fractionally distilled under reduced pressure
  6. customThe desired product recovered
  7. customa boiling point (b.p.) of 62°-64° C./0.15 mm Hg

来源与证据

ORD记录
ord-cd6c544d691047e28572b2af8207df9c
来源数据集
uspto-grants-1988_02
专利号
US04722806

关联笔记

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