氢氧化锂 → 2-甲硫基嘧啶-5-甲酸

HRID 378317笔记

反应方程式

HRID 378317 反应方程式
[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([O:11]CC)=[O:10])=[CH:5][N:4]=1.[Li+].[OH-]>O1CCOCC1>[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][N:4]=1

参与物

4

反应物 2

HCID 3939氢氧化锂HCID 104427162-甲硫基-5-嘧啶羧酸乙酯

产物 1

HCID 36317942-甲硫基嘧啶-5-甲酸

试剂、催化剂与溶剂 1

HCID 312751,4-二氧六环溶剂

实验过程

1 Eq. of 2-methylthio-5-ethoxycarbonylpyrimidine were dissolved in dioxane and, after addition of 2 eq. of 2N LiOH, stirred overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in EtOH. After addition of a stoichiometric amount of ethereal HCl, the solution was again evaporated to dryness. Water which was still present was removed by azeotropic drying with toluene once.

后处理

  1. customThe solvent was then removed under reduced pressure
  2. dissolutionthe residue was dissolved in EtOH
  3. additionAfter addition of a stoichiometric amount of ethereal HCl
  4. customthe solution was again evaporated to dryness
  5. customWater which was still present was removed
  6. dry with materialby azeotropic drying with toluene once

来源与证据

ORD记录
ord-e11576c0d11348c29903a3f377fa8274
来源数据集
uspto-grants-2000_02
专利号
US06030972

反应笔记

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