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碘化钾 → (2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid methyl ester
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 碘化钾 | HCID 4875 | — |
| 反应物 | 1,3-二氯丙酮 | HCID 10793 | — |
| 反应物 | 碳酸氢铯 | HCID 10796 | — |
| 反应物 | 4-(三氟甲基)硫代苯甲酰胺 | HCID 2734823 | — |
| 反应物 | 4-氯甲基-2-[4-(三氟甲基)苯基]-1,3-噻唑 | HCID 2736625 | — |
| 反应物 | (S)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester | HCID 68616579 | — |
| 产物 | (2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid methyl ester | HCID 68617708 | — |
反应步骤
In analogy to the procedure described in example 14 b], (2S)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester (example 17 d]) was reacted with 4-chloromethyl-2-(4-trifluoromethyl-phenyl)-thiazole (prepared from 4-trifluoromethyl-thiobenzamide and 1,3-dichloroacetone in analogy to the procedure described in example 4 a]) in the presence of cesium carbonate and potassium iodide to yield (2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid methyl ester as colorless liquid.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US06809110B2 |
| 来源数据集 | uspto-grants-2004_10 |
| ORD ID | ord-195be2c71ae14db385dfcb50b346c7ea |
| 来源说明 | uspto-grants-2004_10 |