4-(苄氧基)-1-(环丙基甲基)吡啶-2(1H)-酮 → 1-(环丙基甲基)-4-羟基吡啶-2(1H)-酮
反应方程式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C:11](=[O:19])[CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH:16]1([CH2:15][N:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]2=[O:19])[CH2:17][CH2:18]1参与物
4
实验过程
A mixture of intermediate D1 (2.0 g, 7.83 mmol) and a catalytic amount of 10% palladium on activated carbon in ethanol (300 ml) was stirred under a hydrogen atmosphere for two hours. The mixture was filtered through diatomaceous earth and the solvent was evaporated in vacuo to yield intermediate D2 (1.3 g, 100%) that was used without further purification.
后处理
- filtrationThe mixture was filtered through diatomaceous earth
- customthe solvent was evaporated in vacuo
来源与证据
- ORD记录
- ord-62fc197bc4f44fafac76cc472207a7eb
- 来源数据集
- uspto-grants-2014_06
- 专利号
- US08748621B2
反应笔记
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