3-氯-2-羟丙基三甲基氯化铵 → 2-Hydroxy-3-(9-oxo-9H-thioxanthen-2-yloxy)-N,N,N-trimethyl-1-propanaminium chloride

HRID 414338笔记

反应方程式

HRID 414338 反应方程式
[Na].[OH:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:17])[C:5]=2[CH:4]=1.[Cl-].[Cl:19][CH2:20][CH:21]([OH:27])[CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]>Cl.C(O)C>[Cl-:19].[OH:27][CH:21]([CH2:20][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:17])[C:5]=2[CH:4]=1)[CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]

参与物

6

反应物 3

HCID 187323-氯-2-羟丙基三甲基氯化铵HCID 5360545钠HCID 97945682-羟基-9H-噻吨-9-酮

产物 1

HCID 135936912-Hydroxy-3-(9-oxo-9H-thioxanthen-2-yloxy)-N,N,N-trimethyl-1-propanaminium chloride

试剂、催化剂与溶剂 2

HCID 313盐酸催化剂HCID 702乙醇溶剂

实验过程

Sodium (1.36 g) was reacted with absolute ethanol (120 mls) and 2-hydroxy-thioxanthone (11.4 g) (prepared by a method analogous to that of H. Christopher and S. Smiles. J.C.S., 1911, 99, 2050-2051) was added. To the stirred refluxing mixture (3-chloro-2-hydroxypropyl)trimethyl ammonium chloride (10.7 g) was added and the mixture refluxed overnight. After adjusting the pH to ca. 4 via the addition of a few drops of 2N isopropanolic hydrogen chloride solution, hot filtration followed by ice bath cooling of the filtrate and filtration gave the crude title compound which was washed with methanol and vacuum dried.

后处理

  1. customprepared by a method analogous to that of H
  2. addition, 1911, 99, 2050-2051) was added
  3. additionwas added
  4. temperaturethe mixture refluxed overnight
  5. customfollowed by ice bath
  6. temperaturecooling of the filtrate and filtration

来源与证据

ORD记录
ord-f353a8dbe8964c8b95120697baa968ca
来源数据集
uspto-grants-1988_12
专利号
US04791213

反应笔记

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