1,4-氧氮六环 → 1-(6-吗啉吡啶-3-基)乙-1-酮

HRID 416229

反应方程式

HRID 416229 反应方程式
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CCO>[N:11]1([C:2]2[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

参与物

4

反应物 2

HCID 80831,4-氧氮六环HCID 27796982-氯-5-乙酰基吡啶

产物 1

HCID 106558851-(6-吗啉吡啶-3-基)乙-1-酮收率 101.9%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

A solution of 32 (1.25 g, 7.9 mmol) and morpholine (2.20 mL, 25.2 mmol) in EtOH (22 mL) was refluxed for 12 h and then evaporated to dryness. The residue was dissolved in EtOAc (200 mL), washed with saturated NaHCO3 (50 mL×2) and brine (50 mL), dried over Na2SO4, filtered and evaporated to afford the title compound 33a (1.66 g, quantitative yield) as a pale yellow solid.

后处理

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in EtOAc (200 mL)
  3. washwashed with saturated NaHCO3 (50 mL×2) and brine (50 mL)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

来源与证据

ORD记录
ord-7a51bdd3b1294f3386219cf986721fc0
来源数据集
uspto-grants-2012_01
专利号
US08088805B2

关联笔记

加载中…