三乙胺 → (S)-(+)-2-甲基丁基磺酸甲酯

HRID 424306

反应方程式

HRID 424306 反应方程式
[CH3:1][C@@H:2]([CH2:5][CH3:6])[CH2:3][OH:4].C(N(CC)CC)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>C1COCC1>[CH3:14][S:15]([O:4][CH2:3][C@@H:2]([CH3:1])[CH2:5][CH3:6])(=[O:17])=[O:16]

参与物

5

反应物 3

HCID 8471三乙胺HCID 31297甲基磺酰氯HCID 2723602S-(-)-2-甲基-1-丁醇

产物 1

HCID 15698189(S)-(+)-2-甲基丁基磺酸甲酯

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂2 次

反应条件

温度
-10 °C

实验过程

To a −25° C. cooled solution of (2S)-2-methylbutan-1-ol (8.8 g) and triethylamine (30 ml) in THF (50 ml), a solution of methanesulfonyl chloride (1.14 g) in THF (10 ml) was drop wise added. After complete addition (15 min) the reaction mixture was further stirred for 2 h at −10° C. then for 30 min at 0° C. It was then filtered over celite and evaporated to dryness to give nearly pure (2S)-2-methylbutyl methanesulfonate as yellowish oil.

后处理

  1. additionwise added
  2. additionAfter complete addition (15 min) the reaction mixture
  3. waitfor 30 min at 0° C
  4. filtrationIt was then filtered over celite
  5. customevaporated to dryness

来源与证据

ORD记录
ord-43eae94417bb4729bb0435bdf9d95ecc
来源数据集
uspto-grants-2012_01
专利号
US08105662B2

关联笔记

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