参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 三乙胺 | HCID 8471 | — |
| 反应物 | 甲基磺酰氯 | HCID 31297 | — |
| 反应物 | S-(-)-2-甲基-1-丁醇 | HCID 2723602 | — |
| 溶剂 | 四氢呋喃 | HCID 8028 | — |
| 产物 | (S)-(+)-2-甲基丁基磺酸甲酯 | HCID 15698189 | — |
反应步骤
To a −25° C. cooled solution of (2S)-2-methylbutan-1-ol (8.8 g) and triethylamine (30 ml) in THF (50 ml), a solution of methanesulfonyl chloride (1.14 g) in THF (10 ml) was drop wise added. After complete addition (15 min) the reaction mixture was further stirred for 2 h at −10° C. then for 30 min at 0° C. It was then filtered over celite and evaporated to dryness to give nearly pure (2S)-2-methylbutyl methanesulfonate as yellowish oil.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US08105662B2 |
|---|
| 来源数据集 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-43eae94417bb4729bb0435bdf9d95ecc |
|---|
| 来源说明 | uspto-grants-2012_01 |
|---|
