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盐酸 → 3-[1-(1-hydroxy-ethyl)-1H-indol-3-yl]-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione

HRID 427770
笔记
打印预览

反应方程式

HRID 427770 反应方程式
C[O:2][CH:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]2[C:15](=[O:33])[NH:16][C:17](=[O:32])[C:18]=2[C:19]2[C:27]3[C:22](=[CH:23][C:24]([N+:28]([O-:30])=[O:29])=[CH:25][CH:26]=3)[N:21]([CH3:31])[CH:20]=2)=[CH:6]1)[CH3:4].Cl.CCOC(C)=O>C1COCC1.[Cl-].[Na+].O>[OH:2][CH:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]2[C:15](=[O:33])[NH:16][C:17](=[O:32])[C:18]=2[C:19]2[C:27]3[C:22](=[CH:23][C:24]([N+:28]([O-:30])=[O:29])=[CH:25][CH:26]=3)[N:21]([CH3:31])[CH:20]=2)=[CH:6]1)[CH3:4]
参与物实验过程后处理来源与证据反应笔记

参与物

6

反应物 3

HCID 313盐酸HCID 8857乙酸乙酯HCID 183577163-[1-(1-methoxy-ethyl)-1H-indol-3-yl]-4-(1-methyl-6nitro-1H-indol-3-yl)-pyrrole-2,5-dione

产物 1

HCID 183577193-[1-(1-hydroxy-ethyl)-1H-indol-3-yl]-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione收率 33%

试剂、催化剂与溶剂 2

HCID 8028四氢呋喃溶剂
HCID 57417360
Sodium chloride; water
溶剂

实验过程

To a solution of 3-[l -(1-methoxy-ethyl)-1H-indol-3-yl]-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione (3.75 gm) (from step c) above) in 100 mL of THF was added 2 N HCl (75 mL). The solution was stirred at room temperature for 3 hours, and poured into EtOAc and brine. The layers were separated, and the aqueous layer was extracted with EtOAc. The combined EtOAc layers were dried over magnesium sulfate, and evaporated. The residue was purified by flash chromatography using EtOAc/hexanes to give 1.1 gm (Yield 33%) of 3-[1-(1-hydroxy-ethyl)-1H-indol-3-yl]-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione.

后处理

  1. customThe layers were separated
  2. extractionthe aqueous layer was extracted with EtOAc
  3. dry with materialThe combined EtOAc layers were dried over magnesium sulfate
  4. customevaporated
  5. customThe residue was purified by flash chromatography

来源与证据

ORD记录
ord-c21cafbde05f4bbf99e57cd8905ed91d
来源数据集
uspto-grants-2001_11
DOI
10.6084/m9.figshare.5104873.v1
专利号
US06313143B1

反应笔记

加载中…

本页导航参与物实验过程后处理来源与证据反应笔记