碳酸钾 → 叔丁氧基乙酸

HRID 4371

反应方程式

HRID 4371 反应方程式
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:11][CH2:12][C:13]([O:15]CCCC)=[O:14])([CH3:10])([CH3:9])[CH3:8]>CO.O>[C:7]([O:11][CH2:12][C:13]([OH:15])=[O:14])([CH3:10])([CH3:9])[CH3:8]

参与物

4

反应物 2

HCID 11430碳酸钾HCID 14050415Butyl tert-butoxyacetate

产物 1

HCID 2760998叔丁氧基乙酸

试剂、催化剂与溶剂 1

HCID 22242641Methanol--water (1/1)溶剂

反应条件

温度
0 °C

实验过程

To 100 ml of a 50:50 (v/v) methanol/water solution containing 14.35 g of potassium carbonate, was added n-butyl 2-tert-butoxyacetate (6.50 g, 0.0346 mol). The mixture was heated at reflux for 17 hours and the volatiles removed on a flash evaporator. The remaining solution was cooled to approximately 0° C. and acidified to pH 3-4 with cold 50% aqueous hydrogen chloride. The product was extracted with ether, the ether extract washed with brine and dried over magnesium sulfate, then concentrated in vacuo to give the title compound as a yellow liquid.

后处理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 17 hours
  3. customthe volatiles removed on a flash evaporator
  4. extractionThe product was extracted with ether
  5. extractionthe ether extract
  6. washwashed with brine
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo

来源与证据

ORD记录
ord-683c16909174462faf1b49adbea715f3
来源数据集
uspto-grants-1988_02
专利号
US04725620

关联笔记

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