四氧化硫 → 乙酰乙酸异丙酯

HRID 437726

反应方程式

HRID 437726 反应方程式
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].S(=O)(=O)(O)O.[CH:15](O)(C)C>>[C:1]([O:7][CH:8]([CH3:15])[CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

参与物

4

反应物 3

HCID 1118四氧化硫HCID 3776异丙醇HCID 8868乙酰乙酸乙酯

产物 1

HCID 68329乙酰乙酸异丙酯

实验过程

A solution of ethyl acetoacetate (250 g.) and concentrated sulphuric acid (10 ml.) in isopropanol (1500 ml.) was heated at reflux for 3 hours. The solvent was removed by distillation, the residue was neutralised by treatment with barium carbonate, filtered and distilled under reduced pressure to give isopropyl acetoacetate (139 g.), b.p. 79°-82° C./20 mm Hg, in the form of a colourless liquid.

后处理

  1. temperatureat reflux for 3 hours
  2. customThe solvent was removed by distillation
  3. filtrationfiltered
  4. distillationdistilled under reduced pressure

来源与证据

ORD记录
ord-b6056c242bd844a3a1b4bf0f9035f329
来源数据集
uspto-grants-1977_06
专利号
US04032323

关联笔记

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