聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

HRID 4380

反应方程式

HRID 4380 反应方程式
[C:1](=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1.S(OC)(OC)(=O)=O.O>CC(C)=O>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH3:1])[C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1

参与物

6

反应物 4

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 6497甲基硫酸酯-13C2HCID 11430碳酸钾HCID 152128016-甲氧基-1,2,3,9-四氢咔唑-4-酮

产物 1

HCID 197698301,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one收率 78.2%

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

实验过程

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

后处理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 h
  3. filtrationthe resulting precipitate filtered off

来源与证据

ORD记录
ord-1ac4895b46ac455b903ac181d0e5e30d
来源数据集
uspto-grants-1988_02
专利号
US04725615

关联笔记

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