戊二酸 → HCID 178512828，化合物

HRID 462908

反应方程式

HRID 462908 反应方程式
Cl.N(CCCCC(N)=O)C(N)=N.Cl.Cl.NCCCNCCCCNC(=O)C(O)O.C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.[NH2:42][CH2:43][CH2:44][CH2:45][NH:46][CH2:47][CH2:48][CH2:49][CH2:50][NH:51][C:52](=[O:66])[CH:53]([NH:55][C:56](=[O:65])[CH2:57][CH2:58][CH2:59][CH2:60][NH:61][C:62]([NH2:64])=[NH:63])[OH:54]>O>[NH2:42][CH2:43][CH2:44][CH2:45][NH:46][CH2:47][CH2:48][CH2:49][CH2:50][NH:51][C:52](=[O:66])[CH:53]([NH:55][C:56](=[O:65])[CH2:57][CH2:58][CH2:59][CH2:60][NH:61][C:62]([NH2:64])=[NH:63])[OH:54]

参与物

6

反应物 4

HCID 743戊二酸HCID 133564GlyoxylylspermidineHCID 178478612HCID 178478612，化合物HCID 178479441HCID 178479441，化合物

产物 1

HCID 178512828HCID 178512828，化合物收率 37.1%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂2 次

反应条件

温度
60 °C

实验过程

A mixture of 92.4 mg (0.48 mmole) of 5-guanidinopentanamide hydrochloride, 166.5 mg (0.57 mmole) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 62.8 mg (0.48 mmole) of glutaric acid and 0.1 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture which was then purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 82.5 mg (37.1% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(5-guanidinopentanamido)-2-hydroxyethanamide trihydrochloride.

后处理

  1. additionwas added to the reaction mixture which
  2. customwas then purified in a manner similar to that in Example 1 using CM-Sephadex®

来源与证据

ORD记录
ord-7ecb292195b241efa5d2b94bfa3b0af0
来源数据集
uspto-grants-1985_05
专利号
US04518532

关联笔记

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