聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 4'-三氟甲基二苯基-4-甲醛

HRID 463514

反应方程式

HRID 463514 反应方程式
[Li+].CCC[CH2-].Br[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1.CN(C)[CH:25]=[O:26].O>CCCCCC.C1COCC1>[F:20][C:19]([F:22])([F:21])[C:16]1[CH:17]=[CH:18][C:13]([C:10]2[CH:11]=[CH:12][C:7]([CH:25]=[O:26])=[CH:8][CH:9]=2)=[CH:14][CH:15]=1

参与物

7

反应物 4

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 6228N,N-二甲基甲酰胺HCID 61028正丁基锂HCID 127123491,1'-Biphenyl, 4-bromo-4'-(trifluoromethyl)-

产物 1

HCID 27827124'-三氟甲基二苯基-4-甲醛

试剂、催化剂与溶剂 2

HCID 8028四氢呋喃溶剂2 次HCID 8058正己烷溶剂

实验过程

N-Butyllitium in hexane (95 ml, 1.55M) was added dropwise to 4-Bromo-4'-trifluoromethylbiphenyl (40 g) in 250 ml of THF under N2 at -70° C. After addition the mixture was stirred for a further 10 mins and then dry dimethylformamide (19.49) in a solution of dry tetrahydrofuran (100 ml) was added dropwise. The mixture was then allowed to warm to room temperature in the absence of coolant. After stirring for 1.5 hours water was added and the mixture extracted with ether. The water washed and dried extracts were evaporated to give p-(4-trifluoromethylphenyl)benzaldehyde (34.5 g) m.p. 70°.

后处理

  1. additionAfter addition the mixture
  2. additionwas added
  3. extractionthe mixture extracted with ether
  4. washThe water washed
  5. customdried extracts
  6. customwere evaporated

来源与证据

ORD记录
ord-9d36cafe6e454d688a6364df5c155b1a
来源数据集
uspto-grants-1985_05
专利号
US04520007

关联笔记

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