草酰氯 → (6-Benzyloxy-1H-indol-3-yl)-oxo-acetic acid methyl ester

HRID 490760

反应方程式

HRID 490760 反应方程式
[CH2:1]([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[CH:14][NH:15]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18](Cl)(=[O:22])[C:19](Cl)=[O:20].[CH3:24][O-:25].[Na+]>CCOCC>[CH3:24][O:25][C:18](=[O:22])[C:19]([C:13]1[C:12]2[C:16](=[CH:17][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][CH:11]=2)[NH:15][CH:14]=1)=[O:20]

参与物

5

反应物 3

HCID 65578草酰氯HCID 2608046-苄氧基吲哚HCID 10942334甲醇钠

产物 1

HCID 34181007(6-Benzyloxy-1H-indol-3-yl)-oxo-acetic acid methyl ester

试剂、催化剂与溶剂 1

HCID 3283乙醚溶剂

反应条件

温度
-78 °C

实验过程

To a solution of 6-benzoxyindole (1.05 g, 4.7 mmol) in ether (8 mL) is added oxalyl chloride (0.45 mL) at 0˜5° C., stirred for 2 hrs. The reaction mixture is cooled to −78° C., sodium methoxide (25% w/w in methanol, 2.4 mL) is added, warmed up to room temperature, quenched by water. Solid product is collected by filtration, washed by water and dried under vacuum.

后处理

  1. temperaturewarmed up to room temperature
  2. customquenched by water
  3. filtrationSolid product is collected by filtration
  4. washwashed by water
  5. customdried under vacuum

来源与证据

ORD记录
ord-f97a990fb24c4b1b9c321f775e1f21f9
来源数据集
uspto-grants-2009_05
专利号
US07528160B2

关联笔记

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