聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 1-Benzyl-4-hydroxy-4-(1,4-benzodioxan-5-yl)piperidine

HRID 4971

反应方程式

HRID 4971 反应方程式
C([Li])CCC.Br[C:7]1[C:16]2[O:15][CH2:14][CH2:13][O:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.[CH2:17]([N:24]1[CH2:29][CH2:28][C:27](=[O:30])[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.O>CCCCCC.O1CCCC1>[CH2:17]([N:24]1[CH2:29][CH2:28][C:27]([OH:30])([C:7]2[C:16]3[O:15][CH2:14][CH2:13][O:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参与物

7

反应物 4

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 19220N-苄基哌啶酮HCID 187872685-溴-2,3-二氢-1,4-苯并二氧烷HCID 178418339正丁基锂

产物 1

HCID 190820021-Benzyl-4-hydroxy-4-(1,4-benzodioxan-5-yl)piperidine

试剂、催化剂与溶剂 2

HCID 8028四氢呋喃溶剂2 次HCID 8058正己烷溶剂

反应条件

温度
-60 °C

实验过程

23.3 ml of a 1.6M solution of butyllithium in hexane are added dropwise to a solution, previously cooled to -60° C., of 8 g of 5-bromo-1,4-benzodioxane in 400 ml of tetrahydrofuran. When the addition is complete, the mixture is stirred at -60° C. for 5 minutes and a solution of 8 g of 1-benzylpiperid-4-one in 100 ml of tetrahydrofuran is then added dropwise. The mixture is stirred for 2 hours at -40° C. and then for 2 hours at ambient temperature before hydrolyzing using 80 ml of water.

后处理

  1. additionWhen the addition
  2. stirringThe mixture is stirred for 2 hours at -40° C.
  3. waitfor 2 hours at ambient temperature before hydrolyzing using

来源与证据

ORD记录
ord-c53f731d9de94323887be2d52a3919fc
来源数据集
uspto-grants-1993_09
专利号
US05242933

关联笔记

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