二甲基亚砜 → 6-氨基喹喔啉

HRID 530437

反应方程式

HRID 530437 反应方程式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][CH:8]=[N:7]2)([O-])=O.CS(C)=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][CH:8]=[N:7]2

参与物

5

反应物 2

HCID 679二甲基亚砜HCID 960296-硝基喹喔啉

产物 1

HCID 2378596-氨基喹喔啉收率 90%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 702乙醇溶剂

实验过程

6-Nitro-quinoxaline (3, 5 mmol) was hydrogenated in the presence of 5% Pd/C (50 mg) under at room temperature in ethanol (30 ml) for 6-10 h. After the reaction 2 ml DMSO was added to the mixture and filtered. The filtrate was poured into water (200 ml) and the precipitate was filtered to give 6-amino-quinoxaline (4a-d) (90-95%).

后处理

  1. additionwas added to the mixture
  2. filtrationfiltered
  3. additionThe filtrate was poured into water (200 ml)
  4. filtrationthe precipitate was filtered

来源与证据

ORD记录
ord-5dfbb79f89a84db3bfb1f44b918eb477
来源数据集
uspto-grants-2016_05
专利号
US09353094B2

关联笔记

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