碳酸钾 → 5-硝基-2-(吡咯烷-1-基)吡啶

HRID 541220

反应方程式

HRID 541220 反应方程式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CC#N>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

参与物

5

反应物 3

HCID 11430碳酸钾HCID 31268四氢吡咯HCID 783082-氯-5-硝基吡啶

产物 1

HCID 3168235-硝基-2-(吡咯烷-1-基)吡啶收率 93.2%

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

反应条件

温度
60 °C

实验过程

A mixture of 2-chloro-5-nitropyridine (1.58 g, 10.00 mmol, 1.00 equiv), pyrrolidine (710 mg, 10.00 mmol, 1.00 equiv) and potassium carbonate (2.76 g, 20.00 mmol, 2.00 equiv) in CH3CN (20 mL) was stirred at 60° C. in an oil bath. After 2 h, the reaction mixture was allowed to reach ambient temperature. The solids were filtered off and the filtrate was concentrated under reduced pressure. The residue was triturated with 1×20 mL of petroleum ether to yield 1.8 g (93%) of the title compound as a yellow solid.

后处理

  1. customto reach ambient temperature
  2. filtrationThe solids were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was triturated with 1×20 mL of petroleum ether

来源与证据

ORD记录
ord-0bdde35aaa0c4ac2b570c8202a064e76
来源数据集
uspto-grants-2014_10
专利号
US08871790B2

关联笔记

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