醋酸 → 2-(4-tert-butylbenzylidene)-3,4-dihydro-1(2H)-naphthalenone

HRID 54587

反应方程式

HRID 54587 反应方程式
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:12]([C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13].[OH-].[K+].C(O)(=O)C>CO.O>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([CH:20]=[C:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]2=[O:11])=[CH:22][CH:23]=1)([CH3:15])([CH3:13])[CH3:14]

参与物

7

反应物 4

HCID 176醋酸HCID 107241-四氢萘酮HCID 14797氢氧化钾HCID 70324对叔丁基苯甲醛

产物 1

HCID 35712132-(4-tert-butylbenzylidene)-3,4-dihydro-1(2H)-naphthalenone

试剂、催化剂与溶剂 2

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

A mixture of 3,4-dihydro-1(2H)-naphthalenone (4.5 g) and 4-tert-butylbenzaldehyde (5.0 g) was stirred with a solution of 4% potassium hydroxide in methanol (100 ml) for 64 hours at room temperature. The mixture was neutralised with glacial acetic acid, followed by dilution with water (100 ml). The resulting copious white precipitate was filtered off, washed with water and dried in vacuo to give 2-(4-tert-butylbenzylidene)-3,4-dihydro-1(2H)-naphthalenone.

后处理

  1. filtrationThe resulting copious white precipitate was filtered off
  2. washwashed with water
  3. customdried in vacuo

来源与证据

ORD记录
ord-392e6da757734f54a4b9ebfe00572a19
来源数据集
uspto-grants-1997_04
专利号
US05622987

关联笔记

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