氨 → 3-氰基苯甲酰胺

HRID 558317

反应方程式

HRID 558317 反应方程式
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])#[N:3]>ClCCl>[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:1])=[O:8])#[N:3]

参与物

4

反应物 2

HCID 222氨HCID 3084833-氰基苯甲酰氯

产物 1

HCID 769743-氰基苯甲酰胺

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

0.88 Ammonia solution (30 ml) was slowly added to a solution of 3-cyanobenzoyl chloride (10 g, 60.3 mmol) in dichloromethane (100 ml) at 0° C. under nitrogen and the reaction was stirred for 20 minutes. The mixture was filtered and the solid was washed with water (50 ml) then diethylether (50 ml), azeotroped with toluene and dried in vacuo to provide the title compound (9 g) as a white solid.

后处理

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with water (50 ml)
  3. customdiethylether (50 ml), azeotroped with toluene
  4. customdried in vacuo

来源与证据

ORD记录
ord-f90883a111af416d9a39944da9a1fccb
来源数据集
uspto-grants-2011_11
专利号
US08063044B2

关联笔记

加载中…