Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanol → 3-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561663笔记

反应方程式

HRID 561663 反应方程式
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([CH:16]([C:18]2[CH:28]=[CH:27][C:21]3[O:22][C:23]([F:26])([F:25])[O:24][C:20]=3[CH:19]=2)O)[CH2:15][CH2:14]1.ClC1C=CC(C(C2CC2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[CH:13]1([CH:16]([C:18]2[CH:28]=[CH:27][C:21]3[O:22][C:23]([F:25])([F:26])[O:24][C:20]=3[CH:19]=2)[C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)[CH2:14][CH2:15]1

参与物

4

反应物 3

HCID 58392116Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanolHCID 583921383-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indole

产物 1

HCID 583923293-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

实验过程

The title compound was prepared starting from 500 mg (2.82 mmol) of the compound from Example 8A and 644 mg (2.82 mmol) of the compound from Example 157A in analogy to the synthesis of the compound from Example 227. A difference was that stirring at RT was for 45 min. 661 mg (60% of theory) of the target compound were obtained.

后处理

  1. custom661 mg (60% of theory) of the target compound were obtained

来源与证据

ORD记录
ord-eee986084b0a4d77bd32c25c06ff5cbf
来源数据集
uspto-grants-2011_11
专利号
US08063234B2

反应笔记

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