聚丙烯酸钾 → 1-Acryloyloxyethyl 4-acryloyloxybutyl carbonate

HRID 580796

反应方程式

HRID 580796 反应方程式
[C:1](=[O:16])([O:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12](=[O:15])[CH:13]=[CH2:14])[O:2][CH:3](Cl)[CH3:4].[C:17]([O-:21])(=[O:20])[CH:18]=[CH2:19].[K+]>CN(C)C=O.C1OCCOCCOCCOCCOCCOC1>[C:1](=[O:16])([O:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12](=[O:15])[CH:13]=[CH2:14])[O:2][CH:3]([O:21][C:17](=[O:20])[CH:18]=[CH2:19])[CH3:4]

参与物

5

反应物 2

HCID 4429391聚丙烯酸钾HCID 539130511-Chloroethyl 4-acryloyloxybutyl carbonate

产物 1

HCID 539614401-Acryloyloxyethyl 4-acryloyloxybutyl carbonate收率 89.4%

试剂、催化剂与溶剂 2

HCID 2855718-冠醚-6催化剂HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

1-Chloroethyl 4-acryloyloxybutyl carbonate (1.253 g, 5.00 mmol) prepared as described in Example 9 is added to a suspension of freeze dried potassium acrylate (0.606 g, 5.50 mmol) and 18-crown-6 (0.066 g, 0.25 mmol) in dimethylformamide (50 ml) under a dry N2 atmosphere. After 5 days at 20° C. the solvent is removed under reduced pressure and the residue dissolved by adding dichloromethane (60 ml) and water (30 ml). After separating the phases the aqueous layer is extracted with dichloromethane (3×30 ml) and the combined organic phase washed with saturated aqueous sodium hydrogen carbonate (50 ml). The organic phase is dried (MgSO4) and the solvent removed under reduced pressure to give 1.28 g (89%) of the title product. 1H NMR (60 MHz, CDCl3): δ 1.58 (3H, d, J=5 Hz, CH3 --CH), 1.80 (4H, m, CH2 --CH2), 4.24 (4H, m, 2×CH2 --O), 5.7-6.7 (6H, m, 2×CH=CH2), 6.87 (1H, k, J=5 Hz, CH--CH3).

后处理

  1. customAfter 5 days at 20° C. the solvent is removed under reduced pressure
  2. dissolutionthe residue dissolved
  3. additionby adding dichloromethane (60 ml) and water (30 ml)
  4. customAfter separating the phases the aqueous layer
  5. extractionis extracted with dichloromethane (3×30 ml)
  6. washthe combined organic phase washed with saturated aqueous sodium hydrogen carbonate (50 ml)
  7. dry with materialThe organic phase is dried (MgSO4)
  8. customthe solvent removed under reduced pressure

来源与证据

ORD记录
ord-31db1d47c77540518d732bff0ecac1cb
来源数据集
uspto-grants-1999_07
专利号
US05919753

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