对羟基苯丙酸 → 对羟基苯丙酸甲酯

HRID 62838

反应方程式

HRID 62838 反应方程式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.Cl.O1CCOC[CH2:15]1>CO>[CH3:15][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1

参与物

4

反应物 2

HCID 10394对羟基苯丙酸HCID 204431481,4-Dioxane hydrochloride

产物 1

HCID 79706对羟基苯丙酸甲酯收率 100.5%

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

After 3-(4-hydroxy-phenyl)propionic acid (3 g, 18 mmol) was added with MeOH (6 mL), 4M HCl/dioxane solution (18 mL, 72 mmol) was added thereto, and the mixture was stirred at room temperature for 3 hours. The reactant was concentrated, added with EtOAc, and then washed with NaCl aqueous solution. The organic layer was separated, dried with MgSO4, and filtered to obtain the title compound (3.26 g, 99%).

后处理

  1. additionwas added
  2. concentrationThe reactant was concentrated
  3. additionadded with EtOAc
  4. washwashed with NaCl aqueous solution
  5. customThe organic layer was separated
  6. dry with materialdried with MgSO4
  7. filtrationfiltered

来源与证据

ORD记录
ord-ec3f833bd73143d4a3ef43c7709226b4
来源数据集
uspto-grants-2016_09
专利号
US09447044B2

关联笔记

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