溴丁烷 → HCID 178418677，化合物

HRID 6332

反应方程式

HRID 6332 反应方程式
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:13][CH2:12]2)[CH:5]=[CH:4][C:3]=1[OH:22].[CH2:23](Br)[CH2:24][CH2:25][CH3:26].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:23]([O:22][C:3]1[CH:4]=[CH:5][C:6]([O:9][CH2:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:13][CH2:12]2)=[C:7]([F:8])[C:2]=1[F:1])[CH2:24][CH2:25][CH3:26]

参与物

5

反应物 3

HCID 8002溴丁烷HCID 11430碳酸钾HCID 178418594HCID 178418594，化合物

产物 1

HCID 178418677HCID 178418677，化合物

试剂、催化剂与溶剂 1

HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

0.1 mol of 2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxyphenol, 0.11 mol of butyl bromide and 0.11 mol of potassium carbonate are heated for 16 hours at 100° in 100 ml of dimethylformamide (DMF). After cooling, the inorganic salts are filtered off with suction, the filtrate is concentrated, and water is added. 1-butyloxy-2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxybenzene is obtained by extraction with dichloromethane.

后处理

  1. temperatureAfter cooling
  2. filtrationthe inorganic salts are filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. additionwater is added

来源与证据

ORD记录
ord-709fc48404a84ef09737b5887db2472e
来源数据集
uspto-grants-1993_09
专利号
US05248447

关联笔记

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