N-苯基-2-萘胺 → n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide

HRID 639359

反应方程式

HRID 639359 反应方程式
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17](S(C)(=O)=O)[N:16]=[CH:15]3)[CH:8]=[CH:7][N:6]=1)=[O:4].[CH:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][C:27]=1[NH:36]C1C=CC=CC=1>C(#N)C>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17]([NH:36][C:27]2[CH:28]=[CH:29][C:30]4[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH:26]=2)[N:16]=[CH:15]3)[CH:8]=[CH:7][N:6]=1)=[O:4]

参与物

4

反应物 2

HCID 8679N-苯基-2-萘胺HCID 59254867N-methyl-4-(2-(methylsulfonyl)quinazolin-6-yloxy)picolinamide

产物 1

HCID 59254846n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

反应条件

温度
82.5 °C

实验过程

N-methyl[4-(2-methylsulfonylquinazolin-6-yloxy)(2-pyridyl)]carboxamide 15 (1 eq) was treated with 2-naphthylaniline (2 eq) in acetonitrile (1 M) and heated at 80-85° C. The mixture was evaporated and purified on preparative chromatography to give the product.

后处理

  1. customThe mixture was evaporated
  2. custompurified on preparative chromatography
  3. customto give the product

来源与证据

ORD记录
ord-283a518dea0649db9cded85a181d7430
来源数据集
uspto-grants-2010_04
专利号
US07691866B2

关联笔记

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